When I first started DSing I was really taken by the sketch look. I really wanted to do a LO with it. I think Garlou did a post on how she got the look of sketch and I took that and created my own sketch look with photos of my children.
Here is what I did.
1. Found the original photos, when to touchup>sharpen and changed that to 87% (Garlou suggested 100% but it made my image very pixelated.) Then changed the photo to B&W.
2. Go to Touchup> Brightness and Contrast> i changed mine to about negative 20 brightness positive 60 contrast
3. Go to filter> Film Grain Rough, grain type soft, graininess 23 contrast 72
4. Go to touchup>other photo repair> Dodge and Burn brush. This took me a bit to get perfected and even now I'm still not completely settled with the results. I turned the brush to negative 7 and used it to darken eyes, mouth and edges. Then I turned around and changed it to about postitive 14 to brighten eyes and edges in a touch up.
If you click on the link to my photo there is a post by me that has the link to Garlou's recommendations. You'll have to tweak it some also but this should work pretty well

I haven't used the Eyecandy method that Shelley mentioned but I know eyecandy has a lot of perks to offer.
link for my layout:
http://www.scrapbook-bytes.com/galle...at=500&page=10