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It depends on the original layout - you could fill the section with a solid color and then do a selection that way. You might be better off doing it in pieces though so for example start by using the larquee tool to remove straight edge areas. then use the magnetic lassso or even the polygonal lasso to trace the edges of shaped areas.
You may find it even easier just to use the eraser tool and erase all the areas you want gone
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